Healthy Literature
大棗的三萜類化合物通過線粒體活性氧產生可誘導使人類的癌細胞的凋亡细胞死亡
Triterpenoids from Ziziphus jujuba induce apoptotic cell death in human cancer cells through mitochondrial reactive oxygen species production.
/ 文獻筆記 /
大棗鼠李科落葉喬本植物棗，大棗含蛋白質，糖類，有機酸，粘液質，維生素C、P，微量鈣、磷、鐵和多種氨基酸等。近年已有研究顯示提高體內單核－吞噬細胞系統的吞噬功能，保護肝臟，增強肌力和增加體重等作用。而這邊根據Shin M 等人的研究，提取大棗的八種三萜類化合物進行了測試，發現大棗的三萜類化合物可以對於人類的非小細胞肺癌細胞、前列謝癌細胞及乳腺癌細胞通過粒線體的活性氧(ROH)誘導試驗中，結果發現其中4種化合物可以降低癌細胞的存活率，3種可以破壞癌細胞的結構，迫使凋零死亡；這些結果已經讓很多人將大棗視為抗癌新食材。
Ziziphus jujuba var. inermis Rehder is an edible fruit-producing species of the Rhamnaceae family. In the present study, we isolated eight triterpenoids (1-8) from the fruits of Z. jujuba var. inermis and evaluated their apoptotic cell-death-inducing activities in human cancer cell lines (A549, PC-3, and MDA-MB-231). The structures of compounds 1-8 were determined by spectroscopic methods. Among these, four isomers of coumaroyl alphitolic acid showed potent cytotoxic activities on these cancer cells: 3-O-cis-p-coumaroyl alphitolic acid (3), 3-O-trans-p-coumaroyl alphitolic acid (4), 2-O-trans-p-coumaroyl alphitolic acid (5), and 2-O-cis-p-coumaroyl alphitolic acid (6). Moreover, compounds 3-6 induced apoptotic cell death in a concentration-dependent manner. We further investigated the apoptosis-inducing effects of compound 4 in PC-3 cells which triggered the cleavage of procaspase-3, procaspase-7, procaspase-8, bid, and PARP. Compound 4 increased both the mitochondrial reactive oxygen species (ROS) production and the phosphorylation of p38 MAPK (mitogen-activated protein kinase), but decreased the mitochondrial membrane potential. Pretreatment with Mito-TEMPO (a specific mitochondrial-targeted antioxidant) or a specific p38 inhibitor (SB203580) attenuated apoptotic cell death triggered by compound 4 which suggests that compound 4 may induce apoptotic cell death in these cancer cells by increasing the mitochondrial ROS production as well as the subsequent p38 MAPK activation. The study findings provide a rational base to use Ziziphus extracts for cancer treatments in traditional oriental medicine.—文獻摘要
Food Funct. 2018 Jul 17;9(7):3895-3905. doi: 10.1039/c8fo00526e.—文獻出處
https://www.ncbi.nlm.nih.gov/pubmed/29968885 文獻連結
