Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice.
/ 文獻筆記 /
肥胖與腸道微生物菌叢生態失調，腸道障壁和慢性炎症有關。鑑於全世界肥胖症患病率高且不斷增加，安全，有效且廣泛使用的抗肥胖治療將是有益的。本研究經過動物實驗以餵食高脂飲食誘發肥胖及慢性炎症的小鼠，用牛樟芝(Antrodia cinnamomea)（WEAC）的水提取物提供給小鼠，並監測體重，脂肪積累，炎症標記，胰島素敏感性和腸道微生物菌叢生態。其結果發現以餵食高脂飲食餵養的小鼠在攝取牛樟芝(Antrodia cinnamomea)後，通過維持腸道完整性和調整腸道微生物菌叢生態，產生抗致肥胖，抗發炎和抗糖尿病作用。
BACKGROUND: Obesity is associated with gut microbiota dysbiosis, disrupted intestinal barrier and chronic inflammation. Given the high and increasing prevalence of obesity worldwide, anti-obesity treatments that are safe, effective and widely available would be beneficial. We examined whether the medicinal mushroom Antrodia cinnamomea may reduce obesity in mice fed with a high-fat diet (HFD). METHODS: Male C57BL/6J mice were fed a HFD for 8 weeks to induce obesity and chronic inflammation. The mice were treated with a water extract of A. cinnamomea (WEAC), and body weight, fat accumulation, inflammation markers, insulin sensitivity and the gut microbiota were monitored. RESULTS: After 8 weeks, the mean body weight of HFD-fed mice was 39.8±1.2 g compared with 35.8±1.3 g for the HFD+1% WEAC group, corresponding to a reduction of 4 g or 10% of body weight (P小於0.0001). WEAC supplementation reduced fat accumulation and serum triglycerides in a statistically significant manner in HFD-fed mice. WEAC also reversed the effects of HFD on inflammation markers (interleukin-1β, interleukin-6, tumor necrosis factor-α), insulin resistance and adipokine production (leptin and adiponectin). Notably, WEAC increased the expression of intestinal tight junctions (zonula occludens-1 and occludin) and antimicrobial proteins (Reg3g and lysozyme C) in the small intestine, leading to reduced blood endotoxemia. Finally, WEAC modulated the composition of the gut microbiota, reducing the Firmicutes/Bacteroidetes ratio and increasing the level of Akkermansia muciniphila and other bacterial species associated with anti-inflammatory properties. CONCLUSIONS: Supplementation with A. cinnamomea produces anti-obesogenic, anti-inflammatory and antidiabetic effects in HFD-fed mice by maintaining intestinal integrity and modulating the gut microbiota.—文獻摘要
Chang CJ, Lu CC, Lin CS, Martel J, Ko YF, Ojcius DM, Wu TR, Tsai YH, Yeh TS, Lu JJ, Lai HC, Young JD.—文獻出處