Healthy Literature
腸道微生物與大腸癌的關聯
Importance of probiotics in the prevention and treatment of colorectal cancer.
/ 文獻筆記 /
大腸癌(CRC)為常見且致死的癌症之一，腸道微生物具有維持且與健康腸道有關。腸道微生物可協助維持腸道黏膜免疫系統、大分子物質在腸道的吸收、合成人體所需胺基酸及製造維生素與保護腸道免受於病原菌的攻擊。腸道菌叢生態改變或失衡，會引發或促進腸道慢性發炎，造成基因與表微基因改變，導致細胞不正常增生，甚至促進腫瘤形成。益生菌可利用非特異的生理及免疫功能，達到抗腫瘤的活性。根據臨床的研究結果，益生菌能夠干擾致癌物質的形成，以降低致癌物質對於正常細胞的損害，減少腸道腫瘤細胞的產生，進而發揮預防大腸癌的效果。
Colorectal cancer (CRC) remains one of the most common and deadly cancers. Intestinal gut microflora is important to maintain and contributes to several intestinal functions, including the development of the mucosal immune system, absorption of complex macromolecules, synthesis of amino acids/vitamins and the protection against pathogenic microorganisms. It is well known that the gut microbiota changes or dysbiosis may have an essential impact in the initiation and promotion of chronic inflammatory pathways and also have a profound different genetic and epigenetic alterations leading to dysplasia, clonal expansion, and malignant transformation. Probiotic bacteria has antitumor activity with various mechanisms such as nonspecific physiological and immunological mechanisms. This review evaluates the effects of microbiota and probiotics in clinical trials, in vitro and animal model studies that have explored how probiotic against cancer development and also discusses the possible immunomodulatory mechanisms. Several mechanisms alteration of the intestinal microflora; inactivation of cancerogenic compounds; competition with putrefactive and pathogenic microbiota; improvement of the host's immune response; antiproliferative effects via regulation of apoptosis and cell differentiation; fermentation of undigested food; inhibition of tyrosine kinase; reduces the enteropathogenic complications before and after colon cancer surgery and improve diarrhea and it's have been able to create the integrity of gut mucosal and have stimulatory effects on the systemic immune system and prevent the CRC metastasis. Research in clinical trials encouraging findings that support a role of probiotics in CRC prevention and improve the safety and effectiveness of cancer therapy even though additional clinical research is still necessary.—文獻摘要
Eslami M1, Yousefi B2, Kokhaei P1,3, Hemati M2, Nejad ZR2, Arabkari V4, Namdar A5.Author information—文獻出處
J Cell Physiol. 2019 Mar 25. doi: 10.1002/jcp.28473. [Epub ahead of print]
